SNAPC4
Gene Information
- Official Symbol: SNAPC4
- Official Name: small nuclear RNA activating complex polypeptide 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6621
- UniProt: Q5SXM2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016].
- UniProt Summary: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 354
- Expression level (log2 read counts): 5.7
SNAPC4 Expression in NALM6 Cells: 5.7
