UniProt Summary: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.
Pfam DomainsGO Terms
Pfam Domains
LSM
GO Terms
pICln-Sm protein complex
U4 snRNP
methylosome
small nuclear ribonucleoprotein complex
SMN-Sm protein complex
U5 snRNP
U1 snRNP
U2 snRNP
U12-type spliceosomal complex
U2-type catalytic step 2 spliceosome
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
U2-type precatalytic spliceosome
spliceosomal complex assembly
catalytic step 2 spliceosome
spliceosomal complex
import into nucleus
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
nucleocytoplasmic transport
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
RNA binding
intracellular transport
protein-containing complex assembly
RNA metabolic process
establishment of localization in cell
protein-containing complex subunit organization
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)