SPCS1

Entrez Summary: N/A
UniProt Summary: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethanol 0.003 R08 exp437	-2.76
A-395N 10μM R05 exp219	-2.43
Fas-L 44ng/ml R08 exp482	-2.2
IU1-47 25μM R04 exp182	-2.2
CCT251545 0.2μM R06 exp271	-2.11
SNS-032 25μM R07 exp401	-2.07
CAY10603 0.55μM R08 exp467	-2.02
Cannabidiol 20μM R08 exp466	-2
Hydroxychloroquine 30μM R08 exp490	-1.92
Cyclosporin-A 3μM R07 exp348	-1.89
GSK626616 14μM R08 exp485	-1.85
Ibrutinib 1μM R07 exp372	-1.81
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.8
Metformin 100 to 150μM on day4 R04 exp170	-1.8
MLN-4924 2μM R00 exp22	-1.78
MS023 2μM R03 exp134	-1.77
Dihydrosphingosine 8μM R08 exp476	-1.76
Salubrinal 20μM R07 exp399	-1.76
Etoposide 10μM R00 exp20	-1.7
Isoniazid 100μM R08 exp494	1.93
VHL-ligand-1 20μM R07 exp421	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution