TRAPPC8

Gene Information

Official Symbol: TRAPPC8
Official Name: trafficking protein particle complex 8
Aliases and Previous Symbols: N/A
Entrez ID: 22878
UniProt: Q9Y2L5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. {ECO:0000269|PubMed:21525244}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.6
CFI-400945 25μM R08 exp469	-2.15
INK128 0.2μM R02 exp70	-2.1
Monensin 0.3μM R08 exp507	-2.09
Taxol 0.002μM R01 exp54	-2.06
DABN racemic mixture R03 exp93	-2
Deferoxamine 11μM R07 exp350	-1.97
PF-06409577 20μM R07 exp389	-1.87
GSK-J4 1-1.25μM to day4 R07 exp363	-1.84
Olaparib 4μM R08 exp512	-1.84
LLY-284 2.6μM R06 exp291	1.93
PFI-3 10μM R03 exp144	2.08
Colchicine 0.009μM R05 exp215	2.13
Fas-L 44ng/ml R08 exp482	2.48

Gene	Correlation
PRIM1	0.563
POLR2J3	0.483
VPS54	0.459
TRAPPC11	0.445
OGFR	0.432
VPS52	0.426
AATF	0.425
COPB1	0.425
TYMS	0.423
ATP6V1A	0.422
UTP20	0.418
CDC45	0.416
TFIP11	0.414
ATP6V1C1	0.407

Global Fraction of Cell Lines Where Essential: 630/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	23/28
bone	25/26
breast	26/33
central nervous system	43/56
cervix	4/4
colorectal	15/17
esophagus	11/13
fibroblast	0/1
gastric	14/16
kidney	18/21
liver	17/20
lung	57/75
lymphocyte	15/16
ovary	24/26
pancreas	20/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	21/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	25/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 2283
Expression level (log2 read counts): 6.77

Expression Distribution