TTC7A

Entrez Summary: This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-2.44
Vincristine 0.0005μM R04 exp190	-2.22
DABN racemic mixture R03 exp93	-2.02
MLN-4924 0.2μM R00 exp21	-1.95
LY2090314 0.003μM R08 exp499	-1.86
Colchicine 0.009μM R05 exp215	-1.77
SB743921 0.001μM R05 exp244	-1.76
Sulforaphane 9μM R08 exp525	-1.76
Vinblastine 0.002μM R01 exp60	-1.75
Thapsigargin 0.005μM R07 exp407	-1.71
Chloroquine 32μM R08 exp470	1.74
Pyronaridine 1μM R06 exp295	1.78
VER-155008 3.9μM R06 exp301	1.8
FBS-Wisent 0.1 R07 exp426	1.83
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.4

Gene	Correlation
EFR3A	0.475

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	3/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution