UIMC1
Gene Information
- Official Symbol: UIMC1
- Official Name: ubiquitin interaction motif containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51720
- UniProt: Q96RL1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| histone H2A K63-linked deubiquitination |
| BRCA1-A complex |
| signal transduction involved in G2 DNA damage checkpoint |
| histone deubiquitination |
| K63-linked polyubiquitin modification-dependent protein binding |
| G2 DNA damage checkpoint |
| protein K63-linked deubiquitination |
| double-strand break repair via nonhomologous end joining |
| non-recombinational repair |
| positive regulation of DNA repair |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of response to DNA damage stimulus |
| negative regulation of cell cycle G2/M phase transition |
| signal transduction in response to DNA damage |
| regulation of DNA repair |
| histone binding |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| response to ionizing radiation |
| double-strand break repair |
| cell cycle checkpoint |
| positive regulation of DNA metabolic process |
| regulation of cell cycle G2/M phase transition |
| regulation of response to DNA damage stimulus |
| negative regulation of cell cycle phase transition |
| protein deubiquitination |
| nuclear body |
| protein modification by small protein removal |
| negative regulation of cell cycle process |
| regulation of DNA metabolic process |
| histone modification |
| covalent chromatin modification |
| response to radiation |
| regulation of cell cycle phase transition |
| DNA repair |
| negative regulation of cell cycle |
| chromatin organization |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| protein modification by small protein conjugation or removal |
| chromosome organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.476 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5188
- Expression level (log2 read counts): 6.43
Expression Distribution
UIMC1 Expression in NALM6 Cells: 6.43
