VAPA
Gene Information
- Official Symbol: VAPA
- Official Name: VAMP associated protein A
- Aliases and Previous Symbols: N/A
- Entrez ID: 9218
- UniProt: Q9P0L0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204}.
Pfam Domains GO Terms
Pfam Domains
| Motile Sperm |
GO Terms
| FFAT motif binding |
| positive regulation by host of viral release from host cell |
| modulation by host of viral release from host cell |
| negative regulation by host of viral genome replication |
| positive regulation by host of viral genome replication |
| negative regulation by host of viral process |
| modulation by host of viral genome replication |
| positive regulation of viral release from host cell |
| positive regulation by host of viral process |
| protein folding in endoplasmic reticulum |
| modulation by host of viral process |
| endoplasmic reticulum exit site |
| regulation of viral release from host cell |
| positive regulation of viral genome replication |
| endoplasmic reticulum organization |
| negative regulation of viral genome replication |
| azurophil granule membrane |
| positive regulation of viral life cycle |
| COPII-coated vesicle budding |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| Golgi vesicle budding |
| negative regulation of viral life cycle |
| sphingolipid biosynthetic process |
| regulation of viral genome replication |
| vesicle budding from membrane |
| negative regulation of viral process |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| bicellular tight junction |
| membrane lipid biosynthetic process |
| membrane fusion |
| protein localization to endoplasmic reticulum |
| vesicle |
| regulation of viral life cycle |
| microtubule cytoskeleton |
| sphingolipid metabolic process |
| modification of morphology or physiology of other organism |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| membrane lipid metabolic process |
| regulation of viral process |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| protein folding |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| nuclear membrane |
| microtubule binding |
| protein domain specific binding |
| vesicle organization |
| cadherin binding |
| Golgi vesicle transport |
| endomembrane system organization |
| neutrophil degranulation |
| protein heterodimerization activity |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of locomotion |
| lipid biosynthetic process |
| myeloid leukocyte activation |
| Golgi membrane |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| neuron projection development |
| perinuclear region of cytoplasm |
| regulated exocytosis |
| protein localization to organelle |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| exocytosis |
| neuron development |
| interspecies interaction between organisms |
| membrane organization |
| leukocyte activation |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| regulation of locomotion |
| secretion by cell |
| neuron differentiation |
| endoplasmic reticulum |
| positive regulation of intracellular signal transduction |
| export from cell |
| cell activation |
| immune effector process |
| cell death |
| secretion |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
| intracellular transport |
| generation of neurons |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3985
- Expression level (log2 read counts): 6.73
Expression Distribution
VAPA Expression in NALM6 Cells: 6.73
