Pfam Domains GO Terms
| Fer2 |
| Fer2 2 |
| FAD binding 5 |
| Ald Xan dh C |
| CO deh flav C |
| Ald Xan dh C2 |
| xanthine oxidase activity |
| negative regulation of vasculogenesis |
| xanthine catabolic process |
| xanthine dehydrogenase activity |
| xanthine metabolic process |
| purine nucleobase catabolic process |
| molybdopterin cofactor binding |
| negative regulation of vascular endothelial growth factor signaling pathway |
| negative regulation of endothelial cell differentiation |
| negative regulation of cellular response to vascular endothelial growth factor stimulus |
| nucleobase catabolic process |
| regulation of vasculogenesis |
| regulation of vascular endothelial growth factor signaling pathway |
| regulation of cellular response to vascular endothelial growth factor stimulus |
| purine nucleobase metabolic process |
| 2 iron, 2 sulfur cluster binding |
| positive regulation of p38MAPK cascade |
| FAD binding |
| regulation of endothelial cell differentiation |
| negative regulation of endothelial cell proliferation |
| regulation of p38MAPK cascade |
| negative regulation of epithelial cell differentiation |
| nucleobase metabolic process |
| sarcoplasmic reticulum |
| purine nucleotide catabolic process |
| lactation |
| negative regulation of protein kinase B signaling |
| purine-containing compound catabolic process |
| flavin adenine dinucleotide binding |
| nucleotide catabolic process |
| nucleoside phosphate catabolic process |
| body fluid secretion |
| electron transfer activity |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of reactive oxygen species metabolic process |
| negative regulation of blood vessel morphogenesis |
| nucleobase-containing small molecule biosynthetic process |
| peroxisome |
| negative regulation of vasculature development |
| negative regulation of epithelial cell proliferation |
| organophosphate catabolic process |
| mammary gland development |
| regulation of endothelial cell proliferation |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| iron ion binding |
| regulation of epithelial cell differentiation |
| negative regulation of cellular response to growth factor stimulus |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of endopeptidase activity |
| regulation of reactive oxygen species metabolic process |
| electron transport chain |
| positive regulation of peptidase activity |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of protein kinase B signaling |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| regulation of cysteine-type endopeptidase activity |
| regulation of cellular response to growth factor stimulus |
| regulation of vasculature development |
| purine nucleotide metabolic process |
| regulation of epithelial cell proliferation |
| positive regulation of proteolysis |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| negative regulation of protein phosphorylation |
| gland development |
| regulation of endopeptidase activity |
| generation of precursor metabolites and energy |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of peptidase activity |
| negative regulation of phosphorylation |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic cyclic compound catabolic process |
| regulation of body fluid levels |
| negative regulation of intracellular signal transduction |
| nucleobase-containing small molecule metabolic process |
| positive regulation of MAPK cascade |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| small molecule biosynthetic process |
| negative regulation of protein modification process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| protein homodimerization activity |
| organophosphate metabolic process |
| negative regulation of developmental process |
| oxidation-reduction process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| PT-1 25μM R07 exp392 | -1.92 |
| AICAR 240μM R05 exp211 | -1.9 |
| MK2206 4μM R08 exp504 | -1.8 |
| PF-06409577 20μM R07 exp389 | 1.71 |
| Cyclosporin-A 0.8μM R07 exp347 | 1.72 |
| Deguelin 0.05μM R02 exp69 | 1.72 |
| BI-2536 0.02μM R03 exp96 | 2.19 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution