ARNT

Gene Information

Official Symbol: ARNT
Official Name: aryl hydrocarbon receptor nuclear translocator
Aliases and Previous Symbols: N/A
Entrez ID: 405
UniProt: P27540
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013].
UniProt Summary: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5217
Expression level (log2 read counts): 5.7

Expression Distribution

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.73
Dimethyloxaloylglycine 100μM R05 exp229	6.65

Gene	Correlation
HIF1A	0.524
SLC16A7	0.42
HGC6.3	0.415

PAS
HLH
PAS 3

aryl hydrocarbon receptor binding
positive regulation of hormone biosynthetic process
positive regulation of protein sumoylation
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
sequence-specific double-stranded DNA binding
positive regulation of hormone metabolic process
positive regulation of vascular endothelial growth factor receptor signaling pathway
enhancer binding
mRNA transcription by RNA polymerase II
regulation of protein sumoylation
positive regulation of glycolytic process
mRNA transcription
regulation of hormone biosynthetic process
positive regulation of vascular endothelial growth factor production
positive regulation of erythrocyte differentiation
regulation of vascular endothelial growth factor production
regulation of vascular endothelial growth factor receptor signaling pathway
regulation of hormone metabolic process
positive regulation of ATP metabolic process
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
regulation of erythrocyte differentiation
nuclear receptor activity
RNA polymerase II transcription factor complex
regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of glycolytic process
positive regulation of carbohydrate metabolic process
embryonic placenta development
regulation of carbohydrate catabolic process
positive regulation of myeloid cell differentiation
positive regulation of endothelial cell proliferation
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of ATP metabolic process
regulation of DNA-templated transcription in response to stress
regulation of endothelial cell proliferation
xenobiotic metabolic process
positive regulation of protein modification by small protein conjugation or removal
positive regulation of small molecule metabolic process