ASH1L
Gene Information
- Official Symbol: ASH1L
- Official Name: ASH1 like histone lysine methyltransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 55870
- UniProt: Q9NR48
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}.
Pfam Domains GO Terms
Pfam Domains
| Bromodomain |
| PHD |
| BAH |
| SET |
GO Terms
| uterine gland development |
| tarsal gland development |
| histone H3-K36 dimethylation |
| uterus morphogenesis |
| histone methyltransferase activity (H3-K36 specific) |
| sebaceous gland development |
| histone H3-K36 methylation |
| histone methyltransferase activity (H3-K9 specific) |
| interleukin-6 production |
| negative regulation of acute inflammatory response |
| peptidyl-lysine dimethylation |
| histone H3-K9 methylation |
| histone methyltransferase activity (H3-K4 specific) |
| histone H3-K9 modification |
| uterus development |
| decidualization |
| maternal placenta development |
| histone H3-K4 methylation |
| negative regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of acute inflammatory response |
| maternal process involved in female pregnancy |
| sperm motility |
| flagellated sperm motility |
| histone lysine methylation |
| peptidyl-lysine methylation |
| post-embryonic development |
| histone methylation |
| cilium or flagellum-dependent cell motility |
| cilium-dependent cell motility |
| chromosome |
| bicellular tight junction |
| protein methylation |
| protein alkylation |
| negative regulation of inflammatory response |
| single fertilization |
| cytokine production |
| placenta development |
| negative regulation of MAPK cascade |
| fertilization |
| DNA packaging |
| female pregnancy |
| negative regulation of defense response |
| multi-multicellular organism process |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| macromolecule methylation |
| DNA conformation change |
| methylation |
| peptidyl-lysine modification |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| histone modification |
| covalent chromatin modification |
| skin development |
| chromatin binding |
| negative regulation of protein phosphorylation |
| gland development |
| reproductive structure development |
| reproductive system development |
| negative regulation of phosphorylation |
| transcription by RNA polymerase II |
| skeletal system development |
| negative regulation of intracellular signal transduction |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| developmental process involved in reproduction |
| chromatin organization |
| regulation of MAPK cascade |
| regulation of defense response |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| peptidyl-amino acid modification |
| animal organ morphogenesis |
| Golgi apparatus |
| multi-organism reproductive process |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| DNA binding |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-47 25μM R04 exp182 | -2.24 |
| Trientine 500μM R08 exp534 | -1.76 |
| SB202190 10μM R03 exp148 | 1.93 |
| SB203580 25μM R03 exp149 | 2.18 |
| PFI-3 10μM R03 exp144 | 2.35 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 10847
- Expression level (log2 read counts): 6.95
Expression Distribution
ASH1L Expression in NALM6 Cells: 6.95
