CCAR2
Gene Information
- Official Symbol: CCAR2
- Official Name: cell cycle and apoptosis regulator 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 57805
- UniProt: Q8N163
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of DNA damage checkpoint |
| DBIRD complex |
| positive regulation of cell cycle checkpoint |
| mitochondrial fragmentation involved in apoptotic process |
| regulation of DNA damage checkpoint |
| enzyme inhibitor activity |
| regulation of cell cycle checkpoint |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| RNA polymerase II complex binding |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of protein deacetylation |
| negative regulation of ubiquitin-dependent protein catabolic process |
| regulation of DNA-templated transcription, elongation |
| negative regulation of proteasomal protein catabolic process |
| apoptotic mitochondrial changes |
| nuclear receptor transcription coactivator activity |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| regulation of cellular response to heat |
| negative regulation of response to DNA damage stimulus |
| negative regulation of cellular protein catabolic process |
| negative regulation of intrinsic apoptotic signaling pathway |
| positive regulation of response to DNA damage stimulus |
| regulation of circadian rhythm |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| negative regulation of protein catabolic process |
| response to UV |
| positive regulation of canonical Wnt signaling pathway |
| regulation of ubiquitin-dependent protein catabolic process |
| regulation of intrinsic apoptotic signaling pathway |
| positive regulation of Wnt signaling pathway |
| negative regulation of cell growth |
| regulation of proteasomal protein catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| nuclear chromatin |
| negative regulation of growth |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| rhythmic process |
| regulation of canonical Wnt signaling pathway |
| regulation of protein stability |
| response to light stimulus |
| negative regulation of catabolic process |
| enzyme binding |
| negative regulation of proteolysis |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| mitochondrial matrix |
| regulation of protein catabolic process |
| regulation of apoptotic signaling pathway |
| RNA splicing |
| regulation of cell growth |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| response to radiation |
| mitochondrion organization |
| mRNA processing |
| negative regulation of intracellular signal transduction |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of growth |
| mRNA metabolic process |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular response to DNA damage stimulus |
| negative regulation of catalytic activity |
| regulation of cellular catabolic process |
| RNA processing |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| regulation of catabolic process |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CR131-b 0.005μM R08 exp474 | -2.02 |
| Methotrexate 0.01μM R08 exp501 | -1.93 |
| Nicotine 3000μM R08 exp510 | -1.93 |
| Trientine 500μM R08 exp534 | -1.85 |
| Atovaquone 15μM R08 exp451 | -1.84 |
| Cyclosporin-A 3μM R07 exp348 | 1.76 |
| BH1 1μM R04 exp169 | 1.86 |
| Clomiphene 4.4μM R02 exp68 | 2.6 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.45 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2523
- Expression level (log2 read counts): 7.46
Expression Distribution
CCAR2 Expression in NALM6 Cells: 7.46
