CHID1

Entrez Summary: N/A
UniProt Summary: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed:20724479}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.01μM R03 exp130	-1.94
Pterostilbene 16μM R02 exp78	-1.87
NFN1 1μM R03 exp100	-1.85
Nicotinamide 1000μM R03 exp101	-1.76
Lead acetate 2000μM R08 exp498 no dilution day6	-1.73
UM0129480 7μM R02 exp85	-1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chitin binding
oligosaccharide binding
negative regulation of cytokine production involved in inflammatory response
regulation of cytokine production involved in inflammatory response
lysosomal lumen
late endosome
platelet degranulation
negative regulation of inflammatory response
trans-Golgi network
negative regulation of defense response
lysosome
negative regulation of cytokine production
regulation of inflammatory response
negative regulation of response to external stimulus
carbohydrate metabolic process
regulation of cytokine production
regulated exocytosis
regulation of defense response
innate immune response
exocytosis
defense response to other organism
secretion by cell
export from cell
regulation of response to external stimulus
secretion
negative regulation of multicellular organismal process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
regulation of response to stress
extracellular space
negative regulation of response to stimulus
immune response
extracellular region
vesicle-mediated transport
membrane