CPSF2

Entrez Summary: N/A
UniProt Summary: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 630/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	28/28
bone	22/25
breast	28/33
central nervous system	48/56
cervix	4/4
colorectal	15/17
esophagus	10/13
fibroblast	1/1
gastric	12/15
kidney	19/21
liver	17/20
lung	59/75
lymphocyte	12/14
ovary	22/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	12/15
prostate	1/1
skin	23/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	18/22
urinary tract	27/29
uterus	5/5

Expression Distribution

mRNA 3-end processing by stem-loop binding and cleavage
mRNA cleavage and polyadenylation specificity factor complex
mRNA cleavage
mRNA polyadenylation
histone mRNA metabolic process
RNA polyadenylation
termination of RNA polymerase II transcription
DNA-templated transcription, termination
mRNA 3-end processing
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
RNA phosphodiester bond hydrolysis
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
nucleic acid phosphodiester bond hydrolysis
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
intracellular protein transport