DIS3L

Gene Information
  • Official Symbol: DIS3L
  • Official Name: DIS3 like exosome 3'-5' exoribonuclease
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 115752
  • UniProt: Q8TF46
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016].
  • UniProt Summary: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'→5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 7041
  • Expression level (log2 read counts): 6.36

Expression Distribution

  • Last modified: 2025/12/10 20:19
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