DNMBP

Entrez Summary: N/A
UniProt Summary: Scaffold protein that links dynamin with actin- regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcipotriol 5μM R08 exp464	-2.09
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.98
Dinaciclib 0.007μM R07 exp355	-1.72
Mitomycin-C 0.06μM R08 exp503	1.7
WNT3A 44ng/ml R08 exp537	1.71
PU-H71 1μM R08 exp515	1.73
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.79
Curcumin 6.5μM R06 exp277	1.87
Epigallocatechin gallate 20μM R05 exp230	2.18

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi stack
Rho guanyl-nucleotide exchange factor activity
presynapse
regulation of Rho protein signal transduction
regulation of cell shape
cell-cell junction
regulation of Ras protein signal transduction
synapse
aging
regulation of small GTPase mediated signal transduction
cytoskeleton
regulation of cell morphogenesis
Golgi apparatus
regulation of anatomical structure morphogenesis
intracellular signal transduction
regulation of intracellular signal transduction