FXR1

Entrez Summary: N/A
UniProt Summary: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA strand annealing activity
ribonucleoprotein granule
translation regulator activity
costamere
positive regulation of gene silencing by miRNA
positive regulation of posttranscriptional gene silencing
polysome
cytoplasmic ribonucleoprotein granule
mRNA 3-UTR binding
regulation of gene silencing by miRNA
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
positive regulation of translation
regulation of gene silencing
negative regulation of translation
negative regulation of cellular amide metabolic process
dendritic spine
positive regulation of cellular amide metabolic process
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
postsynaptic density
axon
muscle organ development
regulation of mRNA metabolic process
glutamatergic synapse
regulation of translation
neuronal cell body
regulation of cellular amide metabolic process
muscle structure development
protein heterodimerization activity
posttranscriptional regulation of gene expression
perinuclear region of cytoplasm
regulation of cellular catabolic process
nucleolus
protein homodimerization activity
apoptotic process
regulation of catabolic process
negative regulation of cellular protein metabolic process