GRXCR1

Entrez Summary: This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010].
UniProt Summary: May play a role in actin filament architecture in developing stereocilia of sensory cells. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCCP 1μM R00 exp11	-1.88
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.78
TRAIL 50ng/ml R00 exp36	-1.73
Radicicol 0.16μM R05 exp242	-1.72
Pterostilbene 16μM R02 exp78	1.74
UM131593 0.1μM R01 exp58	1.86
Vinblastine 0.002μM R01 exp60	1.93

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vestibular receptor cell differentiation
vestibular receptor cell development
kinocilium
protein disulfide oxidoreductase activity
inner ear receptor cell stereocilium organization
stereocilium
hair cell differentiation
inner ear receptor cell development
inner ear receptor cell differentiation
mechanoreceptor differentiation
microvillus
electron transfer activity
cell redox homeostasis
negative regulation of phosphatase activity
negative regulation of dephosphorylation
sensory perception of sound
sensory perception of mechanical stimulus
regulation of phosphatase activity
electron transport chain
inner ear development
regulation of dephosphorylation
ear development
epidermal cell differentiation
epidermis development
generation of precursor metabolites and energy
negative regulation of hydrolase activity
sensory organ development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
neuron projection development
epithelial cell differentiation
molecular function
negative regulation of catalytic activity
neuron development
cellular homeostasis
oxidation-reduction process
sensory perception
neuron differentiation
epithelium development
plasma membrane bounded cell projection organization