HOXC10

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.002μM R01 exp54	-2.07
S-trityl-L-cysteine 0.5μM R05 exp243	-1.81
Aminopterin 0.005μM R07 exp335	-1.77
CCCP 0.1μM R00 exp10	-1.75
Rapamycin 0.001μM R08 exp429	1.7
NN-Dimethylsphingosine 2.5μM R08 exp508	1.85
UNC2400 2μM R03 exp156	1.85
S-DABN 8μM R03 exp112	2.07
SGC2096 2.6μM R03 exp153	2.07
Taxol 0.004μM R03 exp103	2.5

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spinal cord motor neuron cell fate specification
proximal/distal pattern formation
neuron fate specification
spinal cord motor neuron differentiation
negative regulation of cold-induced thermogenesis
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
cell fate specification
spinal cord development
neuromuscular process
embryonic appendage morphogenesis
embryonic limb morphogenesis
regulation of cold-induced thermogenesis
appendage morphogenesis
limb morphogenesis
central nervous system neuron differentiation
limb development
appendage development
anterior/posterior pattern specification
cell fate commitment
nuclear body
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
embryonic morphogenesis
positive regulation of cell population proliferation
embryo development
central nervous system development
neuron differentiation
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
nervous system process
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
neurogenesis