IFIT5

Entrez Summary: N/A
UniProt Summary: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). {ECO:0000269|PubMed:23317505, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:23774268, ECO:0000269|PubMed:25092312, ECO:0000269|PubMed:26334375}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.79
2-Methoxyestradiol 0.2μM R01 exp40	1.93
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.96

IkappaB kinase complex
RNA cap binding
poly(U) RNA binding
single-stranded RNA binding
negative regulation of viral genome replication
tRNA binding
apical part of cell
negative regulation of viral life cycle
regulation of viral genome replication
ruffle membrane
negative regulation of viral process
double-stranded DNA binding
regulation of viral life cycle
positive regulation of I-kappaB kinase/NF-kappaB signaling
defense response to virus
regulation of viral process
negative regulation of multi-organism process
actin cytoskeleton
regulation of symbiosis, encompassing mutualism through parasitism
regulation of I-kappaB kinase/NF-kappaB signaling
response to virus
intracellular membrane-bounded organelle
innate immune response
regulation of multi-organism process
defense response to other organism
positive regulation of intracellular signal transduction
immune effector process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
RNA binding
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
immune response