IFT74

Entrez Summary: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis–frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017].
UniProt Summary: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269|PubMed:23990561}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	-1.98
AICAR 240μM R05 exp211	-1.75
Nocodazole 0.1μM R03 exp94	-1.74
UM0011500 5μM R05 exp245	1.71
2-Methoxyestradiol 0.55μM R07 exp310	1.74
Bortezomib 0.05μM R00 exp7	1.74
Momordin-Ic 10μM R08 exp506	1.84
MSC2530818 10μM R07 exp379	1.98
Rifampicin 10μM R00 exp32	2.02
All-trans-Retinoic-Acid 8μM R07 exp333	2.16
Bortezomib 0.005μM R00 exp6	2.21
Vinblastine 0.002μM R01 exp60	2.31
CCCP 1μM R00 exp11	2.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

keratinocyte development
positive regulation of cell adhesion mediated by integrin
intraciliary transport particle B
beta-tubulin binding
intraciliary transport involved in cilium assembly
ciliary tip
non-motile cilium assembly
regulation of cell adhesion mediated by integrin
intraciliary transport
microtubule-based protein transport
protein transport along microtubule
motile cilium
determination of left/right symmetry
determination of bilateral symmetry
negative regulation of epithelial cell proliferation
specification of symmetry
Notch signaling pathway
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
epithelial cell development
cilium
cytoplasmic vesicle
protein-containing complex localization
microtubule-based movement
keratinocyte differentiation
epidermal cell differentiation
regulation of epithelial cell proliferation
cilium assembly
cilium organization
skin development
chromatin binding
positive regulation of cell adhesion
epidermis development
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
heart development
microtubule-based process