LAYN [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: LAYN
Official Name: layilin
Aliases and Previous Symbols: N/A
Entrez ID: 143903
UniProt: Q6UX15
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for hyaluronate. {ECO:0000269|PubMed:11294894}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-1.93
VE-822 0.04μM R06 exp300	-1.92
FTY720 3μM R08 exp483	-1.91
Heregulin-B 44ng/ml R08 exp486	-1.84
iCRT14 30μM R08 exp492	-1.79
L-BMAA 500 to 750μM on day4 R04 exp185	1.71
Latrunculin-B 10μM R07 exp374	1.71
GSK2606414 1μM R05 exp236	1.8
Fas-L 44ng/ml R08 exp482	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7369
Expression level (log2 read counts): 0.75

Expression Distribution

Last modified: 2025/12/10 20:19
by 127.0.0.1