MEF2D

Entrez Summary: N/A
UniProt Summary: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-2.61
BH1 1μM R04 exp169	-2.14
CI-1040 9.5μM R08 exp472	-2.12
Benzoate 20000μM R08 exp456	-2.03
GSK626616 14μM R08 exp485	-1.89
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.85
YM155 0.0002μM R01 exp61	2.03

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HJURP C
SRF-TF

adult heart development
replacement ossification
endochondral ossification
activating transcription factor binding
positive regulation of vascular smooth muscle cell proliferation
skeletal muscle cell differentiation
regulation of vascular smooth muscle cell proliferation
endochondral bone morphogenesis
chondrocyte differentiation
positive regulation of smooth muscle cell proliferation
histone deacetylase binding
bone morphogenesis
skeletal muscle tissue development
osteoblast differentiation
skeletal muscle organ development
regulation of smooth muscle cell proliferation
cartilage development
bone development
connective tissue development
nuclear chromatin
skeletal system morphogenesis
ossification
striated muscle tissue development
muscle organ development
muscle tissue development
RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
muscle structure development
protein heterodimerization activity
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
heart development
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
circulatory system development
protein homodimerization activity
positive regulation of cell population proliferation
apoptotic process
animal organ morphogenesis
programmed cell death