NCLN

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.55
THZ1 0.06μM R08 exp531	-2.54
NMS-873 0.07μM R07 exp380	-2.21
Chloramphenicol 2μM R00 exp12	-2.01
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2
Trimetrexate 0.03μM R08 exp535	-1.82
Nicotine 3000μM R08 exp510	-1.8
Radicicol 0.16μM R05 exp242	-1.78
DABN 2μM R00 exp16	-1.71
Rapamycin 2μM R07 exp306	1.72
Aminopterin 0.005μM R07 exp335	1.87
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.93
Erlotinib 10μM R05 exp216	2.45
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.78
Arsenate 40μM R06 exp264	4.38

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
TMEM147	0.494
CCDC47	0.409

Nicastrin
Peptidase M28

regulation of protein complex stability
protein stabilization
regulation of protein stability
regulation of protein complex assembly
protein-containing complex
endoplasmic reticulum membrane
regulation of cellular component biogenesis
membrane