PAPD5

Gene Information

Official Symbol: TENT4B
Official Name: terminal nucleotidyltransferase 4B
Aliases and Previous Symbols: N/A
Entrez ID: 64282
UniProt: Q8NDF8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 2μM R00 exp1	-2.54
Parthenolide 2.5μM R05 exp238	-2.1
Dimethyloxaloylglycine 11μM R07 exp314	1.71
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.73
MK-1775 0.32μM R02 exp75	1.74
Thapsigargin 0.005μM R07 exp407	1.81
AICAR 240μM R05 exp211	1.85
Doxycycline 10μM R00 exp18	1.89
HMS-I2 10μM R06 exp288	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3933
Expression level (log2 read counts): 4.96

Expression Distribution

PAP assoc
NTP transf 2

ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
snoRNA polyadenylation
guanylyltransferase activity
ncRNA polyadenylation
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of 3-UTR-mediated mRNA stabilization
regulation of 3-UTR-mediated mRNA stabilization
negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
TRAMP complex
RNA 3 uridylation
miRNA catabolic process
polyadenylation-dependent ncRNA catabolic process
polynucleotide adenylyltransferase activity
polyadenylation-dependent RNA catabolic process
snoRNA 3-end processing
snoRNA processing
regulation of nuclear-transcribed mRNA poly(A) tail shortening
histone mRNA catabolic process
snoRNA metabolic process
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of telomere maintenance via telomerase
telomerase RNA binding
miRNA metabolic process
negative regulation of telomere maintenance via telomere lengthening
mRNA polyadenylation
DNA-directed DNA polymerase activity
histone mRNA metabolic process
ncRNA catabolic process
RNA polyadenylation
negative regulation of telomere maintenance
negative regulation of DNA biosynthetic process
ncRNA 3-end processing
negative regulation of mRNA catabolic process
regulation of telomere maintenance via telomerase
negative regulation of RNA catabolic process
regulation of telomere maintenance via telomere lengthening
negative regulation of mRNA metabolic process
mRNA 3-end processing
regulation of telomere maintenance
DNA biosynthetic process