PFDN1

Entrez Summary: N/A
UniProt Summary: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.49
Sulforaphane 9μM R08 exp526 no dilution day6	-2.03
Demecolcine 0.03μM R05 exp228	-1.98
Cryptotanshinone 12μM R05 exp227	-1.84
S-trityl-L-cysteine 0.5μM R05 exp243	-1.7
Epothilone-B 0.0015μM R05 exp231	1.74
Taxol 0.004μM R03 exp103	1.97

Global Fraction of Cell Lines Where Essential: 333/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	11/28
blood	7/28
bone	14/26
breast	10/33
central nervous system	29/56
cervix	3/4
colorectal	6/17
esophagus	6/13
fibroblast	1/1
gastric	6/16
kidney	8/21
liver	7/20
lung	32/75
lymphocyte	4/16
ovary	10/26
pancreas	16/24
peripheral nervous system	4/16
plasma cell	5/15
prostate	0/1
skin	12/24
soft tissue	3/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	17/29
uterus	1/5

Expression Distribution

prefoldin complex
protein folding chaperone
unfolded protein binding
protein folding
DNA-binding transcription factor activity