PHF1

Gene Information

Official Symbol: PHF1
Official Name: PHD finger protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 5252
UniProt: O43189
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Latrunculin-B 10μM R07 exp374	-2.18
Ethanol 0.01 R05 exp234	-2.12
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.78
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.28

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10780
Expression level (log2 read counts): 4.05

Expression Distribution

negative regulation of histone H3-K27 methylation
positive regulation of histone H3-K27 methylation
regulation of histone H3-K27 methylation
ESC/E(Z) complex
negative regulation of histone methylation
nucleosome binding
positive regulation of histone methylation
negative regulation of histone modification
site of double-strand break
negative regulation of chromatin organization
methylated histone binding
regulation of histone methylation
negative regulation of gene expression, epigenetic
positive regulation of histone modification
positive regulation of chromatin organization
negative regulation of chromosome organization
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
regulation of gene expression, epigenetic
regulation of chromosome organization
negative regulation of organelle organization
sequence-specific DNA binding
centrosome
negative regulation of protein modification process
positive regulation of organelle organization
DNA-binding transcription factor activity
chromatin organization
negative regulation of cellular component organization
cellular response to DNA damage stimulus
negative regulation of cellular protein metabolic process
chromosome organization
negative regulation of protein metabolic process
positive regulation of cellular component organization
positive regulation of protein modification process
regulation of organelle organization
positive regulation of transcription, DNA-templated
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process