PRDM4

Entrez Summary: N/A
UniProt Summary: May function as a transcription factor involved in cell differentiation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.34
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.08
MS023 7μM R03 exp135	-1.81
GSK343 3μM R03 exp124	1.75
ABT-702 5μM R07 exp318	1.76
KU-0063794 3.8μM R02 exp71	1.87

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H4-R3 methylation
histone methyltransferase binding
histone arginine methylation
peptidyl-arginine methylation
peptidyl-arginine modification
histone methyltransferase complex
methyltransferase activity
chromatin DNA binding
histone methylation
protein methylation
protein alkylation
macromolecule methylation
methylation
RNA polymerase II regulatory region sequence-specific DNA binding
histone modification
covalent chromatin modification
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
chromatin organization
peptidyl-amino acid modification
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process