PREB

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. {ECO:0000250|UniProtKB:Q9WTV0, ECO:0000250|UniProtKB:Q9WUQ2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sulforaphane 9μM R08 exp525	-2.25
LLY-283 2.6μM R06 exp290	-1.87
Mubritinib 0.2μM R02 exp65	-1.79
Sulforaphane 9μM R08 exp526 no dilution day6	-1.7
NN-Dimethylsphingosine 2.5μM R08 exp508	1.87

Global Fraction of Cell Lines Where Essential: 158/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	5/28
bone	10/26
breast	6/33
central nervous system	25/56
cervix	2/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	6/21
liver	4/20
lung	15/75
lymphocyte	3/16
ovary	6/26
pancreas	0/24
peripheral nervous system	5/16
plasma cell	5/15
prostate	1/1
skin	3/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	5/29
uterus	1/5

Expression Distribution

Sar guanyl-nucleotide exchange factor activity
regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
regulation of COPII vesicle coating
regulation of vesicle targeting, to, from or within Golgi
regulation of ER to Golgi vesicle-mediated transport
protein exit from endoplasmic reticulum
endoplasmic reticulum exit site
GTPase binding
IRE1-mediated unfolded protein response
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
guanyl-nucleotide exchange factor activity
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
cellular response to unfolded protein
cellular response to topologically incorrect protein
protein secretion
establishment of protein localization to extracellular region
response to unfolded protein
protein localization to extracellular region
peptide secretion
establishment of vesicle localization
vesicle localization
response to topologically incorrect protein
endoplasmic reticulum to Golgi vesicle-mediated transport
response to endoplasmic reticulum stress
GTPase activator activity
vesicle organization
regulation of intracellular transport
establishment of organelle localization
Golgi vesicle transport
positive regulation of GTPase activity
regulation of protein complex assembly
regulation of GTPase activity