PRKDC
Gene Information
- Official Symbol: PRKDC
- Official Name: protein kinase, DNA-activated, catalytic subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 5591
- UniProt: P78527
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of response to gamma radiation |
| regulation of response to gamma radiation |
| double-strand break repair via alternative nonhomologous end joining |
| DNA-dependent protein kinase activity |
| DNA-dependent protein kinase-DNA ligase 4 complex |
| pro-B cell differentiation |
| somatic diversification of T cell receptor genes |
| immunoglobulin V(D)J recombination |
| T cell receptor V(D)J recombination |
| somatic recombination of T cell receptor gene segments |
| B cell lineage commitment |
| ectopic germ cell programmed cell death |
| nonhomologous end joining complex |
| programmed cell death involved in cell development |
| negative regulation of immunoglobulin production |
| lymphoid progenitor cell differentiation |
| positive regulation of double-strand break repair via nonhomologous end joining |
| V(D)J recombination |
| negative regulation of cellular senescence |
| telomere capping |
| T cell lineage commitment |
| regulation of double-strand break repair via nonhomologous end joining |
| negative regulation of cell aging |
| somatic recombination of immunoglobulin gene segments |
| positive regulation of double-strand break repair |
| spleen development |
| negative regulation of production of molecular mediator of immune response |
| somatic cell DNA recombination |
| somatic diversification of immunoglobulins |
| somatic diversification of immune receptors via germline recombination within a single locus |
| regulation of cellular senescence |
| protein-DNA complex |
| thymus development |
| protein destabilization |
| T cell differentiation in thymus |
| regulation of cell aging |
| somatic diversification of immune receptors |
| positive regulation of fibroblast proliferation |
| response to gamma radiation |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| double-strand break repair via nonhomologous end joining |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| non-recombinational repair |
| G1 DNA damage checkpoint |
| regulation of immunoglobulin production |
| response to activity |
| somitogenesis |
| positive regulation of DNA repair |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of type I interferon production |
| regulation of double-strand break repair |
| regulation of fibroblast proliferation |
| somite development |
| hematopoietic progenitor cell differentiation |
| mitotic DNA damage checkpoint |
| segmentation |
| telomere maintenance |
| positive regulation of response to DNA damage stimulus |
| telomere organization |
| negative regulation of G1/S transition of mitotic cell cycle |
| double-stranded DNA binding |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| B cell differentiation |
| nuclear chromosome, telomeric region |
| regulation of circadian rhythm |
| negative regulation of immune effector process |
| regulation of DNA repair |
| regulation of type I interferon production |
| DNA damage checkpoint |
| regulation of smooth muscle cell proliferation |
| T cell differentiation |
| regulation of production of molecular mediator of immune response |
| DNA integrity checkpoint |
| intrinsic apoptotic signaling pathway |
| response to ionizing radiation |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| B cell activation |
| immunoglobulin production |
| cellular response to insulin stimulus |
| regulation of cell cycle G1/S phase transition |
| positive regulation of developmental growth |
| peptidyl-serine phosphorylation |
| production of molecular mediator of immune response |
| double-strand break repair |
| cell cycle checkpoint |
| positive regulation of DNA metabolic process |
| peptidyl-serine modification |
| transcription factor complex |
| negative regulation of mitotic cell cycle phase transition |
| anterior/posterior pattern specification |
| regulation of response to DNA damage stimulus |
| DNA recombination |
| response to insulin |
| negative regulation of cell cycle phase transition |
| T cell activation |
| lymphocyte differentiation |
| protein kinase activity |
| protein domain specific binding |
| cell fate commitment |
| activation of innate immune response |
| positive regulation of growth |
| cellular response to peptide hormone stimulus |
| rhythmic process |
| apoptotic signaling pathway |
| regulation of protein stability |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| cellular response to peptide |
| regulation of developmental growth |
| leukocyte differentiation |
| regionalization |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| positive regulation of innate immune response |
| anatomical structure homeostasis |
| enzyme binding |
| regulation of DNA metabolic process |
| positive regulation of response to biotic stimulus |
| protein serine/threonine kinase activity |
| lymphocyte activation |
| response to peptide hormone |
| negative regulation of protein phosphorylation |
| gland development |
| regulation of mitotic cell cycle phase transition |
| pattern specification process |
| response to radiation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| positive regulation of cytokine production |
| regulation of innate immune response |
| regulation of immune effector process |
| response to peptide |
| positive regulation of defense response |
| DNA repair |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| heart development |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| protein-containing complex |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| regulation of growth |
| mitotic cell cycle |
| protein ubiquitination |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of cellular response to stress |
| brain development |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of defense response |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| head development |
| nucleolus |
| positive regulation of immune response |
| circulatory system development |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| apoptotic process |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| protein phosphorylation |
| embryo development |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| cell cycle process |
| response to organonitrogen compound |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| chromosome organization |
| cell activation |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| epithelium development |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| cell cycle |
| defense response |
| positive regulation of developmental process |
| RNA binding |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.491 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A
| Tissue | Fraction Of Cell Lines Where Essential |
|---|
Essentiality in NALM6
- Essentiality Rank: 1637
- Expression level (log2 read counts): 10.57
Expression Distribution
PRKDC Expression in NALM6 Cells: 10.57
