RBBP4

Entrez Summary: N/A
UniProt Summary: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-2.26
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.07
BI-6727 0.0125μM R03 exp97	-1.99
Mdivi-1 15μM R05 exp217	-1.85
Thapsigargin 0.005μM R07 exp407	2

Global Fraction of Cell Lines Where Essential: 287/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	10/28
bone	15/25
breast	15/33
central nervous system	16/56
cervix	0/4
colorectal	4/17
esophagus	10/13
fibroblast	1/1
gastric	5/15
kidney	11/21
liver	10/20
lung	23/75
lymphocyte	4/14
ovary	4/26
pancreas	11/24
peripheral nervous system	14/16
plasma cell	6/15
prostate	0/1
skin	8/24
soft tissue	0/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	14/29
uterus	1/5

Expression Distribution

CAF1C H4-bd
WD40

CAF-1 complex
NURF complex
DNA replication-dependent nucleosome assembly
DNA replication-dependent nucleosome organization
Sin3 complex
NuRD complex
ESC/E(Z) complex
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
centromere complex assembly
negative regulation of G0 to G1 transition
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
regulation of G0 to G1 transition
nucleosomal DNA binding
DNA-dependent ATPase activity
histone exchange
ATP-dependent chromatin remodeling
negative regulation of gene expression, epigenetic
RNA polymerase II distal enhancer sequence-specific DNA binding
histone deacetylase binding
nucleosome assembly
histone binding
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
regulation of signal transduction by p53 class mediator
protein-DNA complex assembly
DNA replication
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
negative regulation of cell cycle process
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of cell cycle
protein-containing complex