RPAP1

Entrez Summary: N/A
UniProt Summary: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-1.93
SNS-032 15μM R08 exp443	-1.83
5-Fluorouracil 20μM R00 exp2	-1.81
MS023 2μM R03 exp134	-1.73
DKK1 89ng/ml R08 exp477	1.74
Menadione 5μM R06 exp292	1.79
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.82
proTAME 5μM R04 exp187	1.83
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.91
Dynasore 10μM R04 exp180	2.25

Global Fraction of Cell Lines Where Essential: 712/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	25/26
breast	33/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	19/21
liver	19/20
lung	73/75
lymphocyte	16/16
ovary	24/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	5/5

Expression Distribution

DNA-directed 5-3 RNA polymerase activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression