SENP1

Gene Information

Official Symbol: SENP1
Official Name: SUMO specific peptidase 1
Aliases and Previous Symbols: N/A
Entrez ID: 29843
UniProt: Q9P0U3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:25406032}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 10μM R00 exp30	-3.49
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.51
Rotenone 2μM R00 exp33	-2.09
UM131593 0.2μM R03 exp106	-2.05
Torin1 0.08μM R02 exp82	-2.04
Nocodazole 0.1μM R03 exp94	-2.02
Rapamycin 1μM R00 exp29	-1.99
Rapamycin 2μM R07 exp306	-1.76
5-Azacytidine 2μM R07 exp330	-1.7
INK128 0.2μM R02 exp70	-1.7
Docetaxel 0.002μM R01 exp45	1.71
ABT-702 5μM R07 exp318	1.84
Lead acetate 990μM R08 exp496	1.92
LY2090314 0.003μM R08 exp500 no dilution day6	1.93
Methotrexate 0.01μM R08 exp501	2.09
Vemurafenib 6.6μM R08 exp434	2.11
LY2090314 0.003μM R08 exp499	2.16
FBS-Wisent 0.1 R07 exp426	2.27
Talazoparib 0.006μM R06 exp299	3.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15432
Expression level (log2 read counts): 5.59

Expression Distribution

SUMO-specific isopeptidase activity
regulation of definitive erythrocyte differentiation
protein desumoylation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of erythrocyte differentiation
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
protein sumoylation
negative regulation of proteolysis involved in cellular protein catabolic process
endopeptidase activity
negative regulation of cellular protein catabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of protein catabolic process
positive regulation of cysteine-type endopeptidase activity
regulation of ubiquitin-dependent protein catabolic process
positive regulation of endopeptidase activity
regulation of proteasomal protein catabolic process
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of myeloid cell differentiation
nuclear membrane
regulation of cysteine-type endopeptidase activity
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
apoptotic signaling pathway
protein modification by small protein removal
negative regulation of catabolic process
peptidyl-lysine modification
negative regulation of proteolysis
positive regulation of proteolysis
regulation of protein catabolic process
focal adhesion
regulation of endopeptidase activity
regulation of peptidase activity
regulation of hemopoiesis
positive regulation of apoptotic process
positive regulation of programmed cell death