SNX33

Entrez Summary: N/A
UniProt Summary: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cleavage furrow formation
macropinocytosis
pinocytosis
negative regulation of protein localization to cell surface
positive regulation of membrane protein ectodomain proteolysis
plasma membrane tubulation
positive regulation of protein localization to cell surface
regulation of membrane protein ectodomain proteolysis
cytokinetic process
regulation of protein localization to cell surface
negative regulation of endocytosis
extrinsic component of membrane
mitotic cytokinesis
endosome organization
phosphatidylinositol binding
plasma membrane organization
cytoskeleton-dependent cytokinesis
cytokinesis
negative regulation of cellular protein localization
plasma membrane invagination
protein import
cytoplasmic vesicle membrane
membrane invagination
regulation of endocytosis
positive regulation of protein catabolic process
endosomal transport
cytoplasmic vesicle
vesicle organization
positive regulation of cellular protein localization
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
endomembrane system organization
positive regulation of catabolic process
negative regulation of transport
cell division
regulation of cellular protein localization
regulation of vesicle-mediated transport
endocytosis
mitotic cell cycle process