SOSTDC1

Entrez Summary: N/A
UniProt Summary: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269|PubMed:15020244}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of determination of dorsal identity
mammary gland bud morphogenesis
regulation of determination of dorsal identity
BMP receptor activity
morphogenesis of an epithelial bud
BMP binding
negative regulation of cell fate commitment
morphogenesis of an epithelial fold
hair follicle morphogenesis
negative regulation of myoblast differentiation
regulation of cell fate commitment
epidermis morphogenesis
mammary gland duct morphogenesis
mammary gland morphogenesis
negative regulation of BMP signaling pathway
regulation of myoblast differentiation
mammary gland epithelium development
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
odontogenesis of dentin-containing tooth
regulation of BMP signaling pathway
BMP signaling pathway
molting cycle
hair cycle
gland morphogenesis
cellular response to BMP stimulus
response to BMP
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
odontogenesis
mammary gland development
negative regulation of cellular response to growth factor stimulus
negative regulation of canonical Wnt signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of Wnt signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
regulation of canonical Wnt signaling pathway
epithelial tube morphogenesis