TIAL1

Entrez Summary: The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008].
UniProt Summary: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
S-trityl-L-cysteine 0.5μM R05 exp243	-2.59
Diepoxybutane 3μM R07 exp354	-2.14
Rapamycin 10μM R00 exp30	-2.1
Oligomycin-A 2μM R00 exp25	-2.09
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.98
Doxycycline 10μM R00 exp18	-1.87
TRAIL 5ng/ml R00 exp35	-1.86
Campthothecin 0.001μM R06 exp270	-1.81
Dorsomorphin 5μM R07 exp357	-1.75
Pimelic-diphenylamide-106 5μM R00 exp28	-1.75
Docosahexaenoic-acid 50μM R07 exp356	1.7
Trichostatin-A 0.06μM R07 exp415	1.74
SGC2096 2.6μM R03 exp153	1.75
GSK626616 14μM R08 exp485	1.77
Palbociclib 1μM R07 exp382	1.82
Tubastatin-A 2.5μM R07 exp417	1.84
Aminopterin 0.005μM R07 exp335	1.95
LY2090314 0.003μM R08 exp499	2.1
Q15 2.7μM R02 exp79	2.27
Arsenate 40μM R06 exp264	2.36
LY2090314 0.003μM R08 exp500 no dilution day6	2.96

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mRNA 3-UTR AU-rich region binding
stem cell division
cytoplasmic stress granule
fibroblast growth factor receptor signaling pathway
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
lysosome
germ cell development
cellular process involved in reproduction in multicellular organism
cell division
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
developmental process involved in reproduction
gamete generation
enzyme linked receptor protein signaling pathway
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
positive regulation of cell population proliferation
apoptotic process
multi-organism reproductive process
programmed cell death
cell death
cellular response to endogenous stimulus
defense response
RNA binding
reproductive process
reproduction
DNA binding
response to endogenous stimulus
regulation of cell population proliferation
cell development