USP6

Entrez Summary: N/A
UniProt Summary: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:20418905}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

UCH
TBC

cysteine-type endopeptidase activity
activation of GTPase activity
thiol-dependent ubiquitin-specific protease activity
recycling endosome
Rab GTPase binding
nucleic acid binding
calmodulin binding
lysosome
GTPase activator activity
protein deubiquitination
protein modification by small protein removal
positive regulation of GTPase activity
regulation of GTPase activity
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
regulation of vesicle-mediated transport
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
positive regulation of hydrolase activity
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
intracellular protein transport
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
organic substance catabolic process
positive regulation of molecular function
cellular catabolic process
establishment of localization in cell