VPREB1
Gene Information
- Official Symbol: VPREB1
- Official Name: V-set pre-B cell surrogate light chain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7441
- UniProt: P12018
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
- UniProt Summary: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15124
- Expression level (log2 read counts): 8.01
VPREB1 Expression in NALM6 Cells: 8.01
