YTHDF1

Entrez Summary: N/A
UniProt Summary: Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A- containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). {ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
35°C R06 exp302	-2
Bortezomib 0.005μM R00 exp6	-1.99
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.99
Chloramphenicol 20μM R00 exp13	-1.98
Hippuristanol 0.12μM R08 exp488	-1.75
Nocodazole 0.2μM R00 exp24	-1.75
Colchicine 0.009μM R05 exp215	-1.74
Nifuroxazide 1μM R01 exp51	2.27
Docetaxel 0.002μM R01 exp45	2.39
BI-2536 0.001μM R01 exp41	2.42

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N6-methyladenosine-containing RNA binding
regulation of antigen processing and presentation
positive regulation of translational initiation
regulation of axon guidance
regulation of long-term synaptic potentiation
ribosome binding
regulation of translational initiation
memory
positive regulation of translation
learning
positive regulation of cellular amide metabolic process
regulation of axonogenesis
regulation of synaptic plasticity
regulation of chemotaxis
learning or memory
cognition
regulation of cell morphogenesis involved in differentiation
regulation of translation
regulation of cellular amide metabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
regulation of cell morphogenesis
regulation of neuron projection development
posttranscriptional regulation of gene expression
behavior
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
regulation of locomotion
regulation of cellular component movement
regulation of anatomical structure morphogenesis
regulation of response to external stimulus
nervous system process
RNA binding
generation of neurons
positive regulation of cellular protein metabolic process
neurogenesis