GSR

Gene Information
  • Official Symbol: GSR
  • Official Name: glutathione-disulfide reductase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 2936
  • UniProt: P00390
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010].
  • UniProt Summary: Maintains high levels of reduced glutathione in the cytosol.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 12254
  • Expression level (log2 read counts): 6.15

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1