TOM1L2
Gene Information
- Official Symbol: TOM1L2
- Official Name: target of myb1 like 2 membrane trafficking protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 146691
- UniProt: Q6ZVM7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017].
- UniProt Summary: Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12200
- Expression level (log2 read counts): 3.84
TOM1L2 Expression in NALM6 Cells: 3.84
