ACAP2

Entrez Summary: N/A
UniProt Summary: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). {ECO:0000269|PubMed:11062263}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	1.86
Latrunculin-B 10μM R07 exp374	2.12

phosphatidylinositol-3,5-bisphosphate binding
endocytic recycling
cellular response to nerve growth factor stimulus
response to nerve growth factor
Rab GTPase binding
endosome membrane
endosomal transport
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
cellular response to growth factor stimulus
response to growth factor
positive regulation of hydrolase activity
cellular response to endogenous stimulus
regulation of hydrolase activity
positive regulation of catalytic activity
response to endogenous stimulus
intracellular transport
positive regulation of molecular function
establishment of localization in cell
vesicle-mediated transport
membrane