ACMSD

Gene Information

Official Symbol: ACMSD
Official Name: aminocarboxymuconate semialdehyde decarboxylase
Aliases and Previous Symbols: N/A
Entrez ID: 130013
UniProt: Q8TDX5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IL-3 9ng/ml R08 exp493	1.72
Mubritinib 0.2μM R01 exp48	1.82
BI-6727 0.001μM R01 exp42	1.96
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.1
2-Methoxyestradiol 0.2μM R01 exp40	2.16
Rapamycin 0.001μM R08 exp429	2.28

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11406
Expression level (log2 read counts): -0.25

Expression Distribution

regulation of quinolinate biosynthetic process
picolinic acid metabolic process
aminocarboxymuconate-semialdehyde decarboxylase activity
picolinic acid biosynthetic process
regulation of de novo NAD biosynthetic process from tryptophan
regulation of tryptophan metabolic process
negative regulation of quinolinate biosynthetic process
tryptophan catabolic process
indole-containing compound catabolic process
indolalkylamine catabolic process
regulation of coenzyme metabolic process
tryptophan metabolic process
indolalkylamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
indole-containing compound metabolic process
aromatic amino acid family catabolic process
regulation of cofactor metabolic process
pyridine-containing compound biosynthetic process
aromatic amino acid family metabolic process
regulation of nucleotide biosynthetic process
pyridine-containing compound metabolic process
secondary metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
hydrolase activity
regulation of cellular amine metabolic process
negative regulation of small molecule metabolic process
alpha-amino acid catabolic process
regulation of nucleotide metabolic process
cellular amino acid catabolic process
regulation of cellular ketone metabolic process
monocarboxylic acid biosynthetic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process