ARHGAP33

Entrez Summary: N/A
UniProt Summary: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cycloheximide 0.02μM R00 exp14	-1.8
CCCP 0.1μM R00 exp10	-1.75
All-trans-Retinoic-Acid 8μM R07 exp333	1.74
Apcin 25μM plus proTAME 2μM R04 exp177	1.94

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of dendritic spine morphogenesis
regulation of dendritic spine development
phosphatidylinositol binding
regulation of dendrite morphogenesis
regulation of postsynapse organization
dendritic spine
regulation of dendrite development
regulation of synapse organization
regulation of synapse structure or activity
GTPase activator activity
regulation of cell morphogenesis involved in differentiation
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
protein kinase binding
regulation of GTPase activity
regulation of cell morphogenesis
regulation of neuron projection development
response to toxic substance
protein-containing complex
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
positive regulation of hydrolase activity
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
regulation of anatomical structure morphogenesis
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
generation of neurons
peptide transport
amide transport
establishment of protein localization
neurogenesis
intracellular signal transduction
positive regulation of molecular function
regulation of cell differentiation
regulation of intracellular signal transduction