ARHGEF26

Gene Information
  • Official Symbol: ARHGEF26
  • Official Name: Rho guanine nucleotide exchange factor 26
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 26084
  • UniProt: Q96DR7
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
  • UniProt Summary: N/A

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 16980
  • Expression level (log2 read counts): 3.4

Expression Distribution

  • Last modified: 2025/12/10 20:19
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