ARR3

Entrez Summary: The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016].
UniProt Summary: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Torin1 0.08μM R02 exp82	-1.74
Docosahexaenoic-acid 50μM R07 exp356	1.73
Hydroxyurea 100μM R07 exp329	1.78
BVD-523 15μM R02 exp67	1.79
NMS-873 0.07μM R07 exp380	1.81
FK-506 5μM R07 exp358	1.84
BI-6727 0.001μM R01 exp42	1.99

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Arrestin N
Arrestin C

opsin binding
G protein-coupled receptor internalization
negative adaptation of signaling pathway
desensitization of G protein-coupled receptor signaling pathway
adaptation of signaling pathway
phosphoprotein binding
negative regulation of G protein-coupled receptor signaling pathway
photoreceptor inner segment
photoreceptor outer segment
receptor internalization
G protein-coupled receptor binding
receptor metabolic process
regulation of G protein-coupled receptor signaling pathway
visual perception
sensory perception of light stimulus
receptor-mediated endocytosis
synapse
endocytosis
import into cell
sensory perception
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
nervous system process
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
vesicle-mediated transport
system process