ATG13

Entrez Summary: The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016].
UniProt Summary: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 1000μM R03 exp101	-1.85
GSK-LSD1 10μM R03 exp123	1.72

piecemeal microautophagy of the nucleus
lysosomal microautophagy
autophagy of nucleus
mitophagy
Atg1/ULK1 kinase complex
protein kinase regulator activity
protein localization to phagophore assembly site
response to mitochondrial depolarisation
selective autophagy
phagophore assembly site
positive regulation of protein targeting to mitochondrion
autophagy of mitochondrion
mitochondrion disassembly
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
autophagosome assembly
organelle disassembly
extrinsic component of membrane
autophagosome organization
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
positive regulation of mitochondrion organization
vacuole organization
positive regulation of intracellular protein transport
macroautophagy
regulation of macroautophagy
regulation of mitochondrion organization
positive regulation of intracellular transport
regulation of intracellular protein transport
process utilizing autophagic mechanism
autophagy
positive regulation of cellular protein localization
activation of protein kinase activity
regulation of autophagy
regulation of intracellular transport
cellular component disassembly
positive regulation of protein transport
mitochondrion organization
positive regulation of establishment of protein localization
protein kinase binding