AWAT1

Entrez Summary: The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009].
UniProt Summary: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.15
CCCP 1μM R00 exp11	-1.93
GSK-J4 1.5μM R08 exp441	-1.85
Oligomycin-A 2μM R00 exp25	-1.85
Geldanamycin 0.01μM R05 exp235	-1.84
Wortmannin 5μM R00 exp38	-1.82
B02 10μM R08 exp453	-1.8
Alda-1 10μM R06 exp262	-1.77
PFI-3 10μM R03 exp144	-1.75
CCT251545 20μM R07 exp326	-1.74
YM155 0.0002μM R01 exp61	-1.7
RO-3307 4.7μM R02 exp80	1.74
All-trans-Retinoic-Acid 8μM R07 exp333	1.78

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

long-chain-alcohol O-fatty-acyltransferase activity
arachidoyl-CoA:1-dodecanol O-acyltransferase activity
wax metabolic process
wax biosynthetic process
arachidonic acid metabolic process
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid derivative metabolic process
fatty acid metabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process