AZIN1

Entrez Summary: N/A
UniProt Summary: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
ODC1	0.477
BRPF1	0.405

Orn Arg deC N
Orn DAP Arg deC

positive regulation of polyamine transmembrane transport
putrescine biosynthetic process from ornithine
ornithine decarboxylase activator activity
ornithine decarboxylase activity
putrescine biosynthetic process
regulation of polyamine transmembrane transport
putrescine metabolic process
ornithine metabolic process
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
regulation of cellular amine metabolic process
negative regulation of protein catabolic process
regulation of cellular ketone metabolic process
ammonium ion metabolic process
positive regulation of transmembrane transport
alpha-amino acid metabolic process
cellular amino acid metabolic process
negative regulation of catabolic process
regulation of protein catabolic process
regulation of small molecule metabolic process
regulation of transmembrane transport
carboxylic acid metabolic process
positive regulation of transport
regulation of catabolic process
oxoacid metabolic process
organic acid metabolic process
negative regulation of protein metabolic process
organonitrogen compound biosynthetic process
positive regulation of catalytic activity
cellular nitrogen compound biosynthetic process
small molecule metabolic process
positive regulation of molecular function
regulation of transport