B3GALT2

Gene Information

Official Symbol: B3GALT2
Official Name: beta-1,3-galactosyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 8707
UniProt: O43825
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008].
UniProt Summary: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. {ECO:0000269|PubMed:9417100, ECO:0000269|PubMed:9582303}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14845
Expression level (log2 read counts): -2.43

Expression Distribution

Screen	Score
HMS-I1 1μM R01 exp46	-1.85
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.7
All-trans-Retinoic-Acid 40μM R07 exp334	1.77

glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
galactosylceramide biosynthetic process
galactolipid biosynthetic process
glycosylceramide biosynthetic process
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
galactosylceramide metabolic process
galactolipid metabolic process
oligosaccharide biosynthetic process
glycosylceramide metabolic process
acetylgalactosaminyltransferase activity
glycosphingolipid biosynthetic process
ceramide biosynthetic process
oligosaccharide metabolic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
protein N-linked glycosylation
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
amide biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
Golgi membrane
cellular amide metabolic process
cellular lipid metabolic process
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process