BDKRB1
Gene Information
- Official Symbol: BDKRB1
- Official Name: bradykinin receptor B1
- Aliases and Previous Symbols: N/A
- Entrez ID: 623
- UniProt: P46663
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| bradykinin receptor activity |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| positive regulation of release of sequestered calcium ion into cytosol |
| negative regulation of blood pressure |
| peptide binding |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of calcium ion transmembrane transport |
| sensory perception of pain |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of calcium ion transport into cytosol |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| positive regulation of leukocyte migration |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| regulation of blood pressure |
| negative regulation of cell growth |
| regulation of leukocyte migration |
| positive regulation of transmembrane transport |
| response to mechanical stimulus |
| negative regulation of growth |
| regulation of calcium ion transport |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| response to lipopolysaccharide |
| neuron projection |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| negative regulation of protein phosphorylation |
| regulation of cell growth |
| cellular calcium ion homeostasis |
| negative regulation of phosphorylation |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| negative regulation of protein modification process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of growth |
| response to bacterium |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| ion homeostasis |
| regulation of cell migration |
| response to lipid |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| cell migration |
| sensory perception |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| cell motility |
| localization of cell |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of immune system process |
| response to abiotic stimulus |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| nervous system process |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| homeostatic process |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Epothilone-B 0.0015μM R05 exp231 | -1.85 |
| Wiskostatin 3μM R07 exp422 | -1.79 |
| CR131-b 0.005μM R08 exp474 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7797
- Expression level (log2 read counts): 1.0
Expression Distribution
BDKRB1 Expression in NALM6 Cells: 1.0
